Product ID:L-ISOLEUCINE, I2752
MSDS Date:07/01/1999
FSC:6505
NIIN:00N092469
Status Code:A
MSDS Number: CJTZK

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

L-ISOLEUCINE

CAS: 73-32-5

RTECS: NR4705000

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INHALATION,
INGESTION, OR SKIN ABSORPTION. MAY CAUSE EYE IRRITATION. MAY CAUSE
SKIN IRRITATION. MATERIAL MAY BE IRRITATING TO MUCOUS MEMBRANES AND
UPPER RESPIRATORY TRACT. TO THE BEST OF MANUFACTURER'S KNOWLEDGE,
THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL PROPERTIES HAVE NOT BEEN
THOROUGHLY INVESTIGATED. ADDITIONAL INFORMATION: THE LEVOROTARY (L)
FORMS OF LEUCINE, ISOLEUCIN E AND VALINE HAVE BEEN FOUND TO HAVE
TUMOR-PROMOTING ACTIVITY FOR BLADDER CARCINOMAS. SCIENCE 231, 843,
21 FEBRUARY 1986.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
SHOES. INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE
ARTIFICIAL R ESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN.
INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON IS CONSCIOUS.
CALL A PHYSICIAN. DISCARD CONTAMINATED CLOTHING AND SHOES.

Extinguishing Media:NON-COMBUSTIBLE. USE EXTINGUISHING MEDIA
APPROPRIATE TO SURROUNDING FIRE CONDITIONS.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPMENT .
Unusual Fire/Explosion Hazard:EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED
MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND
REMOVED. VENTILATE AREA AND WAS H SPILL SITE AFTER MATERIAL PICKUP
IS COMPLETE.

Handling and Storage Precautions:AVOID INHALATION. AVOID CONTACT WITH
EYES, SKIN AND CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. KEEP
TIGHTLY CLOSED. STORE IN A COOL DRY PLACE.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:MECHANICAL EXHAUST REQUIRED.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYEWASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA . WEAR OTHER PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

Melt/Freeze Pt:=288.C, 550.4F
Appearance and Odor:WHITE POWDER.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZING AGENTS.
Hazardous Decomposition Products:TOXIC FUMES OF CARBON MONOXIDE, CARBON
DIOXIDE, NITROGEN OXIDES.

Waste Disposal Methods:DISSOLVE OR MIX THE MATERIAL WITH A COMBUSTIBLE
SOLVENT AND BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGULATIONS.

Toxicological Information:RTECS NUMBER: NR4705000 - ISOLEUCINE, L-.
TOXICITY DATA: IPR-RAT LD50: 6822 MG/KG; ABBIA4 58, 253, 1955. ONLY
SELECTED REGISTRY OF TOXIC EFFECTS OF CHEMICAL SUBSTANCES (RTECS)
DATA IS PRESENTED HERE. SEE ACTUAL ENTRY IN RTECS FOR COMPLETE
INFORMATION.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:REVIEWS, STANDARDS, AND REGULATIONS:
OEL=MAK. OEL-RUSSIA: STEL 5 MG/M3 JAN 1993. NOHS 1974: HZD 81864;
NIS 1; TNF 53; NOS 3; TNE 750. NOES 1983: HZD 81864; NIS 3; TNF
740; NOS 13; TNE 18202; TFE 13865 . EPA TSCA SECTION 8 (B) CHEMICAL
INVENTORY.
State Regulatory Information:

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.